- In benign monoclonal gammopathy:
- Up to 5% of bone marrow cells may be plasma cells
- The incidence of myeloma in the 10 years after diagnosis is <2%
- A normochromic normocytic anaemia is common
- There is an increased susceptibility to viral infections
- Soft-tissue plasma-cell tumours are occasionally found
- (T, F, F, F, F) Patients with benign monoclonal gammopathy need to be distinguished from those with multiple myeloma. In the former, paraprotein levels are low (<3 g/dl) with no anaemia or osteolytic bone lesions and <5% plasma cells in the bone marrow, normal serum albumin, little or no immunoglobulin in the urine and no evidence of progression. They do not require therapy unless they show signs of progression. Up to 20% develop myeloma within 10 years. Soft tissue tumours means not `benign’.